25 days old

Post Doctoral Scholar (Guy Lab)

Lexington, KY 40507
Job Title Post Doctoral Scholar (Guy Lab)
Requisition Number DU07035
Work Location Lexington, KY
Salary Range TBD
Type of Position Student
Position Time Status Full-Time
Required Education


Required Related Experience

A graduate degree in synthetic chemistry, medicinal chemistry, chemical biology, or a related field. Expert in the rational design and execution of multi-step target-oriented synthesis. Proficient and knowledgeable in the methods, instrumentation, and the interpretation of data for NMR, chromatographic separation (analytical/prep HPLC), LC/MS, and other analytical methods used to characterize small molecules. Knowledge of medicinal chemistry principles is desired but not required.

Enjoy working in a dynamic, fast paced team environment. Excellent written, verbal and time managements skills, along with a team oriented and highly motivated demeanor.

Required License/Registration/Certification


Physical Requirements

Sitting and standing for long periods of time. Lifting and carrying up to 10 lbs occasionally.


Monday – Friday. Some nights and weekends required

Job Summary

Prof. Kip Guy is seeking a highly self-motivated, creative, and capable postdoctoral scholar to design and synthesize novel small molecules and support various drug discovery programs within his lab in the University of Kentucky, College of Pharmacy.

The successful candidate will independently design, plan, and execute multi-step organic syntheses and purifications of small molecules for in vitro and in vivo testing. He or she will track structure activity relationships (SAR), structure property relationships (SPR), carry out multi-parameter optimization, and work as part of an interdisciplinary team. The successful candidate will also participate in writing scientific reports, papers, grants, and SOPs as well as have opportunities to present their research outcomes and findings at national and international conferences. Extensive experience in small molecule synthesis is strongly desired.

The Guy lab conducts chemical biology and preclinical drug discovery research aimed at improving patient outcomes by addressing unmet clinical need in the areas of cancers and infectious diseases. Our lab focuses on making high-quality chemical probes that act on potential new targets and using those probes to study changes in disease biology both in vitro and in vivo. Ultimately, these studies serve to validate the novel targets as druggable and provide a chemical lead to start drug discovery. Our highly collaborative and multidisciplinary project teams include synthetic, medicinal, and analytical chemists; structural, cell, and developmental biologists; parasitologists; pharmacologists; and clinicians.

Interested parties should submit a cover letter, curriculum vitae, and brief research summary (under specific request 1).

Skills / Knowledge / Abilities
Does this position have supervisory responsibilities? No
Preferred Education/Experience
Deadline to Apply 04/01/2021
University Community of Inclusion

The University of Kentucky is committed to a diverse and inclusive workforce by ensuring all our students, faculty, and staff work in an environment of openness and acceptance. We strive to foster a community where people of all backgrounds, identities, and perspectives can feel secure and welcome. We also value the well-being of each of our employees and are dedicated to creating a healthy place to work, learn and live. In the interest of maintaining a safe and healthy environment for our students, employees, patients and visitors the University of Kentucky is a Tobacco & Drug Free campus.

As an Equal Opportunity Employer, we strongly encourage veterans, individuals with disabilities, women, and all minorities to consider our employment opportunities.

Any candidate offered a position may be required to pass pre-employment screenings as mandated by University of Kentucky Human Resources. These screenings may include a national background check and/or drug screen.


Posted: 2021-02-04 Expires: 2021-03-06

Career Employment at UK

UK offers fulfilling careers in diverse fields supporting our teaching, research and health care missions. We also offer a compelling benefits package, including a generous retirement savings match and a supportive work environment distinguished by a respect for the unique work-life needs of every individual. Our culture of learning also provides tremendous support and resources for ongoing education, training and development. 

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Post Doctoral Scholar (Guy Lab)

University of Kentucky
Lexington, KY 40507

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